Volume : VIII, Issue : VI, June - 2018

VITAMIN D LEVELS IN PATIENTS WITH BENIGN PROSTATIC HYPERPLASIA

Md Mounuddin, B Laxmikanth, N Srinivas

Abstract :

Background: Benign prostatic hyperplasia (BPH) is most commonly encountered non–neoplastic prostatic disease. It is found in approximately 70% of men in their 60s and nearly all men in their 70s.Recently, it was found that low vitamin D level is linked to increase prostate volume and is an independent risk factor for BPH. Prostatic cells possess specific high affinity receptors for 1,25(OH)2D3.

Aims and Objectives: To estimate serum Vitamin D [25(OH)D3] levels in patients of BPH and in controls.

Materials and Methods: 30 patients(mean age=64.35+9.14 years) of BPH were included along with 30 age–matched controls (mean age=64.35+9.14 years).5ml of venous blood was collected from subjects in plain vial. It was subjected to centrifugation and serum was separated for analysis of 25(OH)D3by direct ELISA  method.

Results: Data was analysed using SPSS (version 12). Independent sample‘t’ test was used for between group comparisons. The mean level of serum vitamin D in cases was 26.8 and it was found to be less as compared to controls (34.1). The level of vitamin D in cases was found to be statistically significant (p value <0.001).

Conclusion: Present study observed lower serum Vitamin D levels in patients of BPH. Recently, Vitamin D receptor (VDR) agonists have been shown to be useful in treating BPH patients. Also VDR expression in normal prostate declines with age and prostate hyperplasia is also strongly associated with age. Thus it can be postulated that Vitamin D deficiency could be a risk factor for development of BPH.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

MD Mounuddin, B Laxmikanth, N Srinivas, VITAMIN D LEVELS IN PATIENTS WITH BENIGN PROSTATIC HYPERPLASIA, INDIAN JOURNAL OF APPLIED RESEARCH : Volume-8 | Issue-6 | June-2018

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