IJSR - International Journal of Scientific Research

Dr. Md. Shihab Uddin; Dr. Yousof AlAbdulkarim; Dr. Alam Ara Shafi; Mohammed Salman Bashir

Volume : VIII, Issue : VIII, August - 2019

A retrospective cohort study of soft tissue and bone sarcomas at a tertiary care center

Dr. Md. Shihab Uddin, Dr. Yousof Alabdulkarim, Dr. Alam Ara Shafi, Mohammed Salman Bashir

Abstract :

Background: Sarcoma, though a rare cancer group, is associated with considerable mortality and morbidity in the overall population and the data is insufficient in Saudi Arabia. The objective of this descriptive study is to characterize the disease and to correlate certain clinical response to the practiced management in addition to better understanding of sarcoma. Methods: This retrospective study was conducted at King Fahad Medical City, Riyadh(KFMC) over a period from 2009 to 2013. The bones and soft tissue sarcoma cases were categorized as newly diagnosed and relapsed cases. Results: Among the total 43 patients 41 were newly diagnosed and 2 were relapsed cases of which 26 (60.5%) belonged to soft tissue sarcoma(STS)and 17(39.5%) had bone sarcoma(BS).Average age was 33.6 years (Mean ± S.D:33.51 ± 17.66). Twenty–nine patients had localized disease whereas 14 patients were already having metastatic disease at presentation. The median follows up time of disease free survival was 39 months. Kaplan â€“ Meier survival curve showed significant association between disease free survival (90.9%) and survival with recurrence (87.5%), P–value 0.036. Tumor grade (P = 0.045) and combined therapy (surgery+/–chemotherapy+/– radiotherapy)(P = 0.047) were statistically significant determinant for survival. Conclusion: The median disease free survival was comparable for our study patients to the reported literature. Surgery combined with chemotherapy with or without radiotherapy either in neo–adjuvant or adjuvant setting carries significantly better overall survival as compared to surgery alone. Future prospective multi–center study is needed in order to characterize and understand sarcoma in our population.