Volume : III, Issue : II, February - 2014

A Simple Spectrophotometric Estimation of Atenolol in Pharmaceutical Formulations

K. Nagaraja Setty , G. V. Ranga Reddy

Abstract :

A simple, accurate, rapid and sensitive spectrophotometric method has been developed for the determination of atenolol in pharmaceutical formulations. The method was based on the formation of chloroform extractable complex of atenolol with wool fast blue, which shows absorbance maxima at 470nm against the reagent blank treated similarly. The method obeys Beer\'s law in the concentration ranges of 50-250 µg/mL. Validation studies are statistically significant as all the statistical parameters are within the acceptance range (% RSD< 2.0 and S.D. < 2.0) for both accuracy and precision study. High recovery and low % RSD reveals the reliability of the method for quantitative study of the proposed method in tablet formulation. The proposed method is simple, rapid accurate, precise, reproducible and economic and can be used for routine quantitative analysis of atenolol in pure and tablet dosage form.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

K. NAGARAJA SETTY , G.V.RANGA REDDY A Simple Spectrophotometric Estimation of Atenolol in Pharmaceutical Formulations International Journal of Scientific Research, Vol.III, Issue.II February 2014

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