IJSR - International Journal of Scientific Research

Dr. Suprotik Paul; Dr. Chaitali Biswas; Dr. Shibani Chakraborty

Volume : VIII, Issue : VIII, August - 2019

COMPARISON OF ORAL PREMEDICATION BETWEEN MIDAZOLAM AND CLONIDINE FOR GENERAL ANAESTHESIA IN ELECTIVE OPEN ABDOMINAL SURGERY

Dr. Suprotik Paul, Dr. Chaitali Biswas, Dr. Shibani Chakraborty

Abstract :

Background and Aim: Premedication is an integral part of general anesthesia. An ideal premedicant is effective and pleasant if taken orally. They have analgesic and antiemetic properties and do not impair cardiovascular stability. Moreover, the premedicants have antisialogogue effect and effectively abolish apprehension of the patient. The present study was undertaken to compare the clinical efficacy of oral clonidine and oral midazolam as preanaesthetic medication to attenuate the cardiovascular responses to laryngoscopy during intubation and extubation and also to compare their effects in relation to sedation and decrease in anxiety. Methods : In this randomized prospective comparative study, 80 (eighty) patients in between the age of 20–60 years with ASA grade I or II posted for elective open abdominal surgeries under general anesthesia were randomly allocated in two groups (n=40). Group M (midazolam)–received 0.5mg/kg of body weight of midazolam orally 90minutes prior to induction of anesthesia and Group C (clonidine)–received 3µg/kg of body weight of clonidine orally 90minutes prior to induction of anesthesia. Hemodynamic parameters were recorded at baseline (just before administration of study drug), just before induction of anaesthesia, just after the endotracheal intubation, then 10, 20, 30, 40 minutes after intubation and just after extubation. Sedation score and anxiety score were assessed just before administration of study drug) and just before induction of anaesthesia. Results:– Oral Clonidine decreased both the heart rate and blood pressure more than oral Midazolam. Clonidine effectively attenuated the cardiovascular stress response associated with laryngoscopy and intubation. But it was also found that oral Midazolam produced significant sedation in comparison to oral Clonidine. Conclusion : Oral clonidine was found to be better in respect to oral midazolam as a premedicant to abolish cardiovascular response during laryngoscopy and intubation with less sedation