IJSR - International Journal of Scientific Research

DR.SACRATIS; DR.MOSES.P.MOORTHY; PROF.AV.SRINIVASAN

Volume : VII, Issue : IV, April - 2018

Electrophysiological Changes In Hypertensive Chronic Kidney Disease Patients with Uremic Neuropathy

Dr. Sacratis, Dr. Moses. P. Moorthy, Prof. Av. Srinivasan

Abstract :

Aim To study about the Electrophysiological changes in hypertensive chronic kidney disease patients with neuropathy. Methods This study is a prospective analytical study carried out in electrophysiological unit of Govt Mohan Kumaramangalam Medical College and Hospital, Salem, Tamilnadu from August 2015 to May 2016. 46 patients aged between 30 to 60 years were chosen for this study. Inclusion criteria Hypertension CKD patients with uremic neuropathy in pre, post dialysis state, post transplant states. Exclusion criteria Uremic neuropathy due to Diabetes mellitus and other causes of CKD are excluded. Results: This Study is done in 46 patients with uremic neuropathy (35 males and 11 females). Nerve Conduct Study (NCS) done in pre dialysis, immediate post dialysis, post transplant state. In pre dialysis state motor nerve conduction study (MNCS) revealed, mean – latency (4.3ms), amplitude (4mv), velocity (42m/s) in right median nerve. Sensory nerve conduction study showed, mean latency (3.6ms), amplitude (8.2 µv), velocity (43.2m/s) In Post dialysis state MNCS showed, mean latency (3.8ms), amplitude (10.9mv), velocity (49m/s) and SNCS showed mean latency (3.4ms), amplitude (15.2 µv) and velocity (51m/s) Post dialysis state showed statistically significant reduction in latency (p<0.001), increase in amplitude (p<0.001) and increase in mean velocity for a transient period. Post transplant patient showed normal latency, (3.2ms) amplitude (10.3mv), velocity (51 m/s). SNCS showed normal latency (2.6ms), amplitude (21.8 µv) and velocity (52 m/s). There is no significant change in F–wave pattern. Conclusion: Electrophysiological studies in hypertension CKD patients’ revealed, uremic neuropathy in pre dialysis state, significant improvement in post dialysis state, and normal electrophysiological studies in post transplant state. This study shows uremic neuropathy itself is an indication of need of renal replacement therapy.