IJSR - International Journal of Scientific Research

Fozail Ahmad; Kalpana; Tanvi; Ravins Dohare

Volume : VI, Issue : VI, June - 2017

Evaluation of the specific hubs in the transcriptional regulatory network (TRN) of Mycobacterium Tuberculosis

Fozail Ahmad, Kalpana, Tanvi, Ravins Dohare

Abstract :

Interaction of molecules in any system is complex, such as protein–protein, gene–gene, gene–mRNA–protein interaction etc. Hence, we are seeing complex behavior of second most life claiming agent Mycobacterium tuberculosis (M. tb) due to rampageous boom across globe for its potentiality to withstand against most drug discovered. It concerns with the robustness of the entire TRN (Transcriptional Regulatory Network) of Mycobacterium tuberculosis. Summary This work has been divided into two approaches; firstly random and secondly directed mode of attacks against nodes in network. Findings have demonstrated that if network is attacked randomly then it would remain unaffected as its overall functionality remains intact. If network attacked in directed mode, it oke into small isolated fragments showing higher path length and hampered flow of information between nodes. Moreover, this implication put forth which can be met with novel discovery and development of drug to cure this acute disease.