Volume : VI, Issue : VII, July - 2017

Evaluation of Wound Healing Potential of Different Topical Formulations of Methanolic Leaf extracts of Tridax Procumbens L. in Rats

Lokesh Prasad M. S, Kalaskar P. Gurunath, S. B. Chandrasekar, Umashankar C, Harisha R

Abstract :

 Tridax procumbens L. (TP) is a common weed that grows in the rice fields of India. Traditionally the leaves of Tridax procumbens has been used for wound healing. However, in experimental studies, equivocal pro and anti–healing action of Tridax procumbens has been demonstrated. The present study evaluates the effect of topical ointment different formulations like Ointments (5%  & 10%), Creams (5% & 10%) and Gels (5% &10%) of the Methanolic leaf extracts of Tridax procumbens(METP) using excision wound model in rats. Excision wounds (2.5 cm, i.d.) were inflicted on depilated back of rats. Formulations of METP were applied twice daily for 21 days on the dermal wound. The parameters observed were Wound area, re–epithelization, vascularity, fioblast number, collagen content. The METP of Ointment, Creams, Gels (10%) and Silver sulphadiazine (1%) Showed statistically very significant (P>0.01) when compared to control group at 21st day. Taken together, the results imply that METP possesses dose dependent pro–healing potential. The Order of potency Silver sulphadiazine> METP Ointment base> METP Cream base > METP Gel base.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Lokesh Prasad M.S, Kalaskar P.Gurunath, S.B. Chandrasekar, Umashankar C, Harisha R, Evaluation of Wound Healing Potential of Different Topical Formulations of Methanolic Leaf extracts of Tridax Procumbens L. in Rats, INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : VOLUME-6 | ISSUE-7 | JULY-2017


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