Impaired Increase of Plasma Abscisic Acid in Response to Oral Glucose Load in Type 2 Diabetes and in Gestational Diabetes

Ravi Yadav; Pranay Gandhi; Lokesh KC

Volume : IV, Issue : IV, April - 2015

Impaired Increase of Plasma Abscisic Acid in Response to Oral Glucose Load in Type 2 Diabetes and in Gestational Diabetes

Ravi Yadav, Pranay Gandhi, Lokesh Kc

Abstract :

The plant hormone abscisic acid (ABA) is present and active in humans, regulating glucose homeostasis. In normal glucose tolerant (NGT) human subjects, plasma ABA (ABAp) increases 5-fold after an oral glucose load. The aim

of this study was to assess the effect of an oral glucose load on ABAp in type 2 diabetes (T2D) subjects. The increase of ABAp in response to

glucose was found to be aogated in T2D patients compared to NGT controls. A similar result was observed in the women with GDM compared to pregnant NGT controls; 8-12 weeks after childbirth, however, fasting ABAp and ABAp response to glucose were restored to normal

in the GDM subjects, along with glucose tolerance. These results indicate an impaired hyperglycemia-induced ABAp increase in T2D and in

GDM and suggest a beneficial effect of elevated ABAp on glycemic control.