INFLUENCE OF PARAQUAT (PQ) INDUCED ACUTE TOXICITY ON BODY WEIGHTS AND HAEMOTOBIOCHEMICAL PARAMETERS IN EXPERIMENTAL RATS

B.Haripriya; M. Lakshman; V.Sudha

Volume : VI, Issue : VII, July - 2017

INFLUENCE OF PARAQUAT (PQ) INDUCED ACUTE TOXICITY ON BODY WEIGHTS AND HAEMOTOBIOCHEMICAL PARAMETERS IN EXPERIMENTAL RATS

B. Haripriya, M. Lakshman, V. Sudha

Abstract :

Paraquat (PQ) is a highly toxic potent herbicide promoted by the United States for use in Mexico to destroy marijuana plants in the year 1955. There have been frequent PQ poisoning incidents which have become a severe public health issue all over world, especially in Asian region. The present experiment was designed to study the acute toxicity effects of PQ on body weights and haemato–biochemical alterations among 32 male Wistar rats (two groups) at different time intervals i.e. 24, 48, and 72 hrs. Group 1 served as control and group 2 rats were injected with PQ at the rate of 24 mg/kg body weight intraperitoneally as a single dose. Average body weight gains were recorded during 24, 48 and 72 hrs of experiment. A day before sacrifice the blood and serum samples were collected from 6 rats in each group for TEC, Hb and platelets, ALT, AST and creatinine respectively. The obtained data was statistically analyzed by using SPSS software.