IJSR - International Journal of Scientific Research

Beatriz Bertolaccini Martinez; Nadja Lys Medeiros Barbosa; Raphael Brito de Almeida Dutra; Luiz Francisley De Paiva

Volume : VIII, Issue : VI, June - 2019

Quercetin on Healing of Infected Cutaneous Wounds of Dexamethasone–treated Rats

Beatriz Bertolaccini Martinez, Nadja Lys Medeiros Barbosa, Raphael Brito De Almeida Dutra, Luiz Francisley De Paiva

Abstract :

PURPOSE: To evaluate the actions of quercetin on healing of infected cutaneous wounds of Dexamethasone–treated rats. MATERIAL AND METHODS: Open cutaneous excision wound was created on the back of the 40 Wistar rats that received dexamethasone for 10 consecutive days. These animals were divided into four groups: Dexamethasone (D), Dexamethasone–Infection (DI), Dexamethasone–Quercetin (DQ), and Dexamethasone–Infection–Quercetin (DIQ). Linear measurements of wound edges were obtained. Skin and subcutaneous tissue were removed for pathological anatomic analysis of the wound. This study has been approved by Universidade do Vale do Sapucaí Ethics Committee on Animal Usage. RESULTS: Wound areas (mm) before and after healing were, respectively, in D (626.4±34.9 vs 338.5±57.8 p>0,05); DI (512.7±31.1 vs 384.2±39.0; p=0.01); DQ (567.5±30.0 vs 334.9±52.5 p>0,05); DIQ (522.1±56,1 vs 306.2±73.1 p>0,05). before and after healing were, respectively, in D (626.4±34.9 vs 338.5±57.8 p>0,05); DI (512.7±31.1 vs 384.2±39.0; p=0.01); DQ (567.5±30.0 vs 334.9±52.5 p>0,05); DIQ (522.1±56,1 vs 306.2±73.1 p>0,05). After wound healing Colony–forming Units, were 88 x 106/ml in DI and 50 x 106/ml in DIQ, p = 0,02. CONCLUSION: Quercetin accelerated healing of infected cutaneous wounds of dexamethasone–treated rats.