Volume : VIII, Issue : VIII, August - 2019

ROLE OF BCL–2 IN THE PATHOGENESIS OF PSORIASIS

Dr Sachin Bajaj, Dr Monika Girdhar, Dr Kapil Jagga

Abstract :

Psoriasis is a common inflammatory skin disease characterized by the epidermal hyperplasia and greatly accelerated turnover. A complex mechanism involving immune dysregulation, enhanced keratinocytic proliferation, inflammation and angiogenesis has been proposed as the pathogenic mechanism of psoriasis. It has been postulated that the increased epidermal thickness and altered tissue architecture observed in psoriasis may be related to an abnormality in the apoptotic pathway. There is aberrant epidermal expression of apoptosis related molecules leading to the suppression of the apoptotic process, while suppression of apoptosis of T lymphocytes leads to the chronic and relapsing character of psoriasis. There is a number of such apoptosis related molecule out of which Bcl–2 gene has gained a unique importance as the inhibitor of apoptosis. In the present study both lesional and non–lesional skin biopsy samples from 30 patients with psoriasis were studied for expression of Bcl–2 protein by immunohistochemical staining.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

ROLE OF BCL-2 IN THE PATHOGENESIS OF PSORIASIS, Dr Sachin Bajaj, Dr Monika Girdhar, Dr Kapil Jagga INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-8 | Issue-8 | August-2019

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