Volume : VIII, Issue : VIII, August - 2019

STUDY OF CLINICAL PROFILE, RISK FACTORS AND PLATELET INDICES IN SPONTANEOUS INTRACEREBRAL BLEED

Dr. Priyanka Ranga, Dr. Abha Dua

Abstract :

INTRODUCTION: Stroke is a devastating medical disease that imposes the greatest burden of disability–adjusted life years (DALYs) of all neurological disorders. Patients with spontaneous intracereal hemorrhage have subtle platelet dysfunction associated with ICH progression and larger ICH size. In our study clinical profile, risk factors and platelet indices were studied in patients of ICH. Platelet indices which includes platelet count, mean platelet volume, plateletcrit and platelet distribution width were compared in case group and control groups and correlated with severity of stroke. Material and method: 50 cases and 50 controls were included in our study group after applying all inclusion and exclusion criteria. Platelet indices (platelet count, MPV, PDW, PCT) were studied in both cases and controls groups. Clinical profiling, risk factors analysis and severity of ICH assessed by NIHSS score were done in cases group. RESULTS: It was found that among all risk factors in cases group, most common risk factors were hypertension, smoking, DM and dyslipidemia (62%, 62%, 54% & 4% respectively) with male preponderance in cases and control groups. Mean Platelet count in cases & controls were 260120±70954 SD & 218020±60845.64 SD respectively with significant statistically (p<0.0002). Mean platelet volume in cases (11.36±0.97 SD) & in controls (9.27±0.78 SD). PDW in cases (15.42±2.79 SD) & in controls (12.74±1.45SD). In both the parameters, difference was found to be statistically significant (p<0.0001). The difference between mean PCT of cases (0.3±0.08 SD) & of controls (0.29±0.05 SD) was not statistically significant (p>0.05). CONCLUSION: To conclude, in our study that ICH patients having significant higher values of MPV, PDW in cases as compare to controls groups and reason postulated to increase in MPV and PDW in cases due to acute inflammation response in ICH patients and ongoing chronic illness. With highest risk factors found in ICH cases were hypertension, smoking, and majority were males.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

STUDY OF CLINICAL PROFILE, RISK FACTORS AND PLATELET INDICES IN SPONTANEOUS INTRACEREBRAL BLEED, Dr.Priyanka Ranga, Dr.Abha Dua INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-8 | Issue-8 | August-2019

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