The Effect of Timing of the Spasmolytic Agent Before Or During Colonoscopy

Fulya YILMAZ DURAN; Erkan OYMACI; Halil YILDIRIM; Murat Yasar OZKALKANLI; Sermin KARAARSLAN; Gunay YILDIZ; Ozgur DURAN; Recep ATCI

Volume : IV, Issue : IV, April - 2015

The Effect of Timing of the Spasmolytic Agent Before Or During Colonoscopy

Fulya Yilmaz Duran, Erkan Oymaci, Halil Yildirim, Murat Yasar Ozkalkanli, Sermin Karaarslan, Gunay Yildiz, Ozgur Duran, Recep Atci

Abstract :

Background: Colonic spasm that encountered during colonoscopy lengthens the process, increases the need for

sedation, makes it difficult to progress within the lumen, may disrupt the display of the colonic mucosa. Use of antispasmodic medication during colonoscopy is controversial. The aim of this study is to determine whether there is any objective benefit on

caecal intubation time and the median total procedure time when hyoscine N butylomide is used as a premedication 15 minutes before the

colonoscopy or by the start of colonoscopy.

Method: A hundred consecutive patients were randomly assigned to receive intravenous 1 mL hyoscine N butylomide containing 20 mg/

mL of the drug, 15 minutes before the procedure (Group 1) or by the start of the procedure (Group 2) in conjunction with our standard initial

medications (midazolam, fentanyl, propofol).

Results: Our analysis demonstrated no statistically significant difference between groups with the ceacel intubation time, the median total

procedure time and mean propofol dose used as anaesthetic. Considering the mean pulse rate and mean arterial pressure, there is a statistically significant difference between the groups during the procedure.

Conclusion: Rapid action and beneficial efficiency support the use of hyoscine N butylomide in diagnostic abdominal procedures, where

spasm may be a problem.