IJSR - International Journal of Scientific Research

Dr. Masrat Jahan; Dr.Mohd Saleem Itoo; Dr. Shaheen Shahdad

Volume : VIII, Issue : VIII, August - 2019

To observe the effect of high fatty diet on the histology of liver in Albino rats.

Dr. Masrat Jahan, Dr. Mohd Saleem Itoo, Dr. Shaheen Shahdad

Abstract :

INTRODUCTION:fat which is an essential component of a balanced diet and very important for many physiological and metabolic processes of the body, if given in excess amount causes hepatic injury MATERIAL AND METHODOLOGY:The present study was carried in the postgraduate department of the anatomy where 30 male albino rats weighing on average 100–150 grams were divided into three groups. Group A served as control. These rats were fed on normal diet containing less that 2% of fat. Group B animals received high fat diet containing >30% of the total caloric requirement. Group C received high fat diet for 10 weeks followed by pure vegetarian diet for next ten weeks. One animal from group A and two from group B were sacrificed at the end of 2nd,4th,6th and 10th weeks, and histopathological changes were recorded. After 10weeks, one animal from group A and two animals from group C were sacrificed at the end of 12th, 14th, 16th, 18th and 20th weeks. Observations were recorded. RESULTS:In our study we found that fat causes histopathological changes in the hepatocytes in a dose and duration dependent manner . Thus we conclude that in the form of steatosis, macro and micro vesicular fatty infiltration, inflammatory changes like periportal inflammation in zone 1,2 and 3.Excess of fat also cause hepatitis if taken for short interval of time. These are dose and duration dependent. In our study we found that fat induced hepatic injury .In summary we found that high content of animal fat in diet causes hepatic injury which is dose and duration dependent.